Vascular tight junction disruption and angiogenesis in spontaneously hypertensive rat with neuroinflammatory white matter injury
Vascular cognitive impairment is a major cause of dementia caused by chronic hypoxia, producing progressive damage to white matter (WM) secondary to blood-brain barrier (BBB) opening and vascular dysfunction.Tight junction proteins (TJPs), which maintain BBB integrity, are lost in acute ischemia.Although angiogenesis is critical for neurovascular r